Kawasaki disease (KD) is a self-limited, systemic vasculitis developing in early childhood. Physical examination showed interfollicular erythema and follicular plugging without skin atrophy or sclerotic change. In heterozygous females affected by an X-linked skin disorder, lesions often appear in a characteristic pattern, the so-called Blaschko's lines. The lines are distinguished from other morphological lines of the skin and do not represent vascular, lymphatic or nervous structures. (C) Blaschko linear, erythematous and pigmented atrophic line with a verrucous part (6-months-old). 7 The majority of LPP. BACKGROUND Lichen planus (LP) with distribution of lesions along Blaschko’s lines is a rare entity, accounting for 0. Background: The system of Blaschko's lines has been insufficiently documented on the head and neck. He noticed that some of his patients had skin disorders. 4 Blaschko lines are invisible in normal skin but may become apparent in various skin conditions. Here we report a case of an 11-year-old female child presented with multiple hyperpigmented and hyperkeratotic papules present over the posterior aspect of right lower extremities along Blaschko’s lines. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. On the back, they form V patterns, while on the stomach they form S patterns. The most frequent variant of LPP is linear, as was observed in the current case, with zosteriform or Blaschkoid LPP being much less common. The genital, perianal, and mucosal areas were normal. There have been many reports of congenital and acquired. The original description by Blaschko referred to a system of lines on the human skin which the linear naevi and dermatoses follow. Though invisible some skin diseases appear themselves according to these patterns creating the visual of these lines. As these cells divide and spread over the growing body, they form swirls and streams that create the lines of Blaschko. ( Bygum et al. Yellow-brown hyperpigmentation following the Blaschko's lines. They remind us of our individuality – that even within our own bodies, no two cells are exactly alike. In 1998, when reporting 2 cases of linear childhood CLE following the lines of Blaschko, Abe et al. Blaschko’s Lines. Blaschko’s lines (BL) are considered systematized cutaneous developmental patterns during embryogenesis that are different from vascular, neural, or lymphatic pathways. 24%-0. . Blaschko's lines also termed as the lines of Blaschko, are believed to represent normal cell development in the skin. The appearance of LPP in our case could not be directly linked to a specific cause because of the ambiguity in the pathogenesis of the disease. Last updated October 06, 2023. TIL Human skin is overlaid with Blaschko’s Lines, a pattern of stripes covering the body from head to toe, invisible unless under UV light or if certain skin conditions manifest them mentalfloss. The nowadays well-known lines of Blaschko form streaks displaying a V-shape or fountain-like pattern on the back, an S-shape or whorled pattern over the lateral aspects of the trunk, and a linear pattern on. The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. 6 Dispersed lesions of classical lichen planus can also occur over the Blaschko lines. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. It is feasible that the latter may. [1][2][3] The lines can be observed in other animals such as cats and dogs. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. 11 The lines are visible and present in S-shaped, V-shaped, or even U-shaped patterns. Herein, we report a patient with patterned cutaneous hypopigmentation with a similar phenotype due to a novel. Multiple organ systems can be involved. Blaschko’s lines were originally described by Dr. Blaschko’s lines, also called the Lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. Most of these cases combined features of LP pigmentosus, LP pilaris, and atrophic LP. Clinical features are heterogeneous. Blaschko’s lines are not visible under normal circumstances but become apparent when certain skin conditions or diseases occur, such as inflammatory disorders or genetic mutations. Discussion. This peculiar association of clinico-pathological. Neither a specific disease nor a predictable symptom of a disease, Blaschko's lines are an invisible pattern built into human DNA [citation. Dossi Cataldo et al. Dear Editor, Lichen striatus (LS) is a self-limiting linear dermatosis that predominantly affects children aged 5 months to 15 years and is distributed along the lines of Blaschko. The main purpose of this article is to introduce the concept of Blaschko's lines into the medical, paramedical, and general biological fields of science, and it is hoped that some inter‐reaction can occur between those who regularly see and study other chromosomal and embryological abnormalities. Multiple lesions arise in a linear fashion along the lines of Blaschko, most commonly along a limb or one side of the trunk or head and neck ; Disseminated superficial actinic porokeratosis (DSAP) This is the most common variety and arises in. Net Letter Nevus comedonicus along Blaschko’s lines Sir, groups of dilated follicular openings filled with black, Nevus comedonicus is an uncommon skin abnormality hard plugs, distributed over left cheek, left arm and first described in 1895 by Kofmann who used the term forearm, left side of the chest [Figure 1], abdomen, left “comedo-nevus”. thought to represent pathways of epidermal cell migration and proliferation during the development of the fetus; become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. These lines are only visible in those with a mosaic The lines are believed to trace the migration of embryonic cells. When there is a big difference between the two. Cutaneous mosaicisms usually manifest by specific patterns on the skin and the archetypic pattern is the system of Blaschko lines, but others include checkerboard, phylloid, large patches without midline separation and lateralization. Mosaicism describes an individual composed of two or more genetically. These lines are. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. Blaschko's lines represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. Blaschko’s lines, also called the lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. Bhutani et al. Close. Hypopigmentation along Blaschko’s lines defines hypomelanosis of Ito (HI). These preliminary results support the ideas that (1) Blaschko's lines represent single clones of epidermal cells; (2) in patients with HI and severe neurological involvement mosaicism, if. 2) 3. Recent studies have suggested that these linear pigmentary anomalies reflect underlying genetic mosaicism. These lines are only visible in those with a mosaic The lines are believed to. The shape of Blaschko represent a pattern assumed on many different nevoid and acquired skin diseases on the humanitarian skin and mucosae. The Stripes on Humans: An Exploration. Method: One hundred eighty-six figures showing skin lesions following Blaschko's lines on the head and neck were collected from literature and patient files,. He noticed that about 150 of his patients all had rashes and moles. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal nerves. Blaschko’s lines are attributed to the migration lines of epidermal cells during embryogenesis and are characterized by a V-shaped pattern on the posterior midline, S-shape on the abdomen, and spiral on the posterior scalp. Incontinentia pigmenti, also known as Bloch-Sulzberger syndrome, is an uncommon sex-linked inherited syndrome reported primarily in females, as it is often lethal to male fetuses in utero. There was high degree of similarity in the shape, orientation, and pattern of these idiopathic pigmented patches with the same of many pigmentary nevi, Blaschko's line of face and with the recently described specific Blaschko's lines for pigmentary nevi as well [Figure 10]. Wenowrecognise Blaschko's lines in many Received 22 April 1993. (B) verrucous formation on the middle digit (3-months-old). This contribution provides an update on the diverse genetic etiologies. The appearance of LPP in our case could not be directly linked to a specific cause because of the ambiguity in the pathogenesis of the disease. Typically these lines are not visible; however. Blaschko’s lines map out a migratory history of ectodermal skin cells after their proliferation and movement from embryonic development into the fully formed organism ; further, skin disorders following these lines may be explained by the mosaicism due to X-chromosome inactivation or early somatic mutations . These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal. Since 1901, when Blaschko lines were first described, the study of mosasicism has helped to elucidate the. , 2005) and the karyotype of a woman with body asymmetry and patchy skin was mos 45,X/46XX,+14 (Becerra-Solana et al. Exogenous linear patterns are caused by external factors. When there is a big difference between the two. Exogenous linear patterns are caused by external factors. The conductor of Blaschko represent ampere pattern assumed by multiple different nevoid and acquired skin diseases on the human. 1,2 There are several terms for this entity, including linear LP, Blaschkolinear LP, and Blaschkoid LP. Blaschko Lines are common skin patterns that were first identified in 1901 by a German dermatologist named Alfred Blaschko. Conditions of the human integumentary system. 7. 1 and 5. 6%) cases. Diagnosis is made based on clinical appearance of 2 to 4 mm, flat-topped, lichenoid papules ranging from red color to flesh color that are distributed linearly and may be discrete or. 62% of all patients with LP [ 1 ]. 4 Blaschko’s original diagrams did not include the lines of the face or scalp; however, the pattern now accepted was later depicted by Happle in 2001 (Figure 6). Citation 58 Linear or zosteriform LP is an uncommon variant that follows the Koebner phenomenon, does not adhere to Blaschko’s lines, and rarely follows a dermatomal arrangement. If occurring on the trunk or extremities, they follow Blaschko lines. Linear cutaneous lupus erythematosus is a rare subset of cutaneous lupus erythematosus (CLE), characterized by skin lesions along Blaschko lines. Blaschko lines correspond with cell migration or growth pathways that are established during embryogenesis. This is also a rare case in which 90% repigmentation was achieved in patient with segmental and nonsegmental vitiligo following Blaschko. Alfred Blaschko in 1901 when he examined over 140 patients with linear skin lesions that followed similar patterns. Physical examinationConfluent and reticulated papillomatosis (CARP), also called confluent and reticulated papillomatosis of Gougerot and Carteaud, is an uncommon skin condition that consists of multiple small, hyperkeratotic macules or papules that coalesce to form patches or plaques with a reticulated (net-like) pattern peripherally. Lichen striatus (LS) is uncommon and occurs most frequently in children. A postzygotic mutational event may lead. Six archetypical patterns of cutaneous mosaicism can so far be distinguished: (1) lines of Blaschko, (2) checkerboard pattern, (3) phylloid pattern, (4) patchy pattern without midline separation, (5) lateralization pattern, and (6) the sash-like pattern (Figs. Blaschko’s lines are a pattern of lines, swirls, and curves on the skin that typically follow geometric shapes like diamonds and ovals and form a V- or S-shaped pattern. in 1986. Linear and whorled nevoid hypermelanosis (LWNH) is a reticulate pigmentary disorder characterized by hyperpigmented macules in a streaky configuration, evolving along Blaschko's lines [ 1, 2, 3 ]. All humans have Blaschko’s lines, but they are usually not visible. 62% of all LP patients. Males and females with certain skin conditions and other conditions will also show it under visible light or UV light. The study was approved by the Institutional Review Board of the Catholic Medical Center Office of Human Research Protection Program (VC17ZESE0096). 24%-0. In the present instance, the linear erythema resolved promptly in response to primary IVIG therapy as with the other KD symptoms, suggestingThese preliminary results support the ideas that (1) Blaschko's lines represent single clones of epidermal cells; (2) in patients with HI and severe neurological involvement mosaicism, if detectable, is best shown in keratinocytes; and (3) the cytogenetic defect in epidermal cells may be directly responsible for the failure of pigmentation in HI. They never cross the anterior truncal midline but run along it. 24% to 0. The most common clinical patterns are streaks and swirls following Blaschko's lines in narrow or broad bands and a block-like distribution. Two years later, Baumann et al. The most common clinical patterns are streaks and swirls following Blaschko's lines in narrow or broad bands and a block-like distribution. '2 DrMoss. These lines are invisible under normal conditions. Here, we report a case of this rare disorder and have put forward an argument why. The lines of Blaschko represent a pattern followed by many skin disorders. Pigmentary nevi represent nevi with altered pigmentation. Introduction. 5 These lines are curved over scalp. In 1992, Moulin et al. The clinical and histologic characteristics of childhood DLE are discussed and a review of the linear manifestations of childhood LE is. 5-1 cm hypopigmented or white macules that merge to form larger patches; Macules cover more than two dermatomes and are often on both sides of the body; Patches are not symmetricalFor example, Blaschko's lines were present in a girl with a karyotype mos 47,XX,+7/45,X (Niessen et al. Blaschko's lines are the pattern assumed by different naevoid and acquired skin diseases on the human skin . Cutaneous conditions can follow Blaschko's lines on the skin, which are thought to reflect patterns of cell migration and clonal expansion during embryonic development of the epidermis. 24%-0. Epidermal genetic mosaicism due to somatic mutations potentially results in an acquired blaschkitis (skin inflammation on Blaschko's lines) triggered by external. They were described and drawn by a German dermatologist, Blaschko, more than 100 years ago. Cutaneous mosaicisms usually manifest by specific patterns on the skin and the archetypic pattern is the system of Blaschko lines, but others include checkerboard, phylloid, large patches without midline separation and lateralization. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. A dermatome is an area of skin that is primarily supplied by a single nerve root: communicating sensation from this skin region to the brain. 5 It has been postulated that the cells along Blaschko lines contain distinct genotypes that may ultimately permit a unique response to stimuli such as. Case Presentation. TLDR. R. 3A 27-year-old Japanese woman presented with small atrophic hyperpigmented macules on her extremities since early childhood. In the case of somatic mutations (cutaneous mosaic ), the spread of the affected cell clone is visualized by the corresponding linear hamartoma (nevus). One of the subjects developmental biologists are interested in is the development of pattern. The lines of Blaschko represent a classic pattern of cutaneous mosaicism and can be observed in a wide variety of skin disorders. 2 They are usually seen on either the scalp, face, trunk, and/or limbs. Dermatoses that follow Blaschko's lines are thought to be caused by a somatic mutation that takes place early in embryogenesis, resulting in a genotypic and phenotypic mosaicism. . For easier comparison, a simplified form of the latter that had fewer. Unilateral distribution of lesions in arm, leg. In this paper, we presented a 47. Blaschko’s Lines. Jackson: The lines of Blaschko: a review and reconsideration: Observations of the cause of certain unusual linear conditions of the skin. Four other patterns of mosaicism are also di. Hypopigmentation along Blaschko’s lines defines hypomelanosis of Ito (HI). Congenital lesions may include incontinentia pigmenti and variants of epidermal nevi. B, Equivalent. Blaschko’s lines, also called the Lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. The eruption affects the lines of Blaschko, which are thought to be embryonic in origin. The lines of Blaschko represent a pattern followed by many skin disorders. Objective: The aim of the study was to elaborate this pattern in a comprehensive way. These lines, which form V patterns on the back and S patterns on the stomach, are a consequence. g. It is generally noted at birth and stabilizes with 1–2 years of progression. They may be unilateral in early non-segmental vitiligo, or in segmental vitiligo when confined to part or all of one or more dermatomes or areas delineated by Blaschko's lines. Paul Blaschko, who first described them in the early 1900s. Objective: The aim of the study was to elaborate this pattern in a comprehensive way. These diseases are hypothesized to be caused by genetic mosaicism resulting from processes such as lyonization or somatic postzygotic mutation. The lines are distinguished from other morphological lines of the skin and do not represent vascular, lymphatic or nervous structures. 1976. Citation 58 Linear or zosteriform LP is an uncommon variant that follows the Koebner phenomenon, does not adhere to Blaschko’s lines, and rarely follows a dermatomal arrangement. Blaschko was the son of a physician and was born in. Pigmentary mosaicism refers to patterned hypo- and/or hyperpigmentation that results from genetic heterogeneity of skin cells. A diagram of the distribution pattern of these lines has since been drawn and is now referred to as the lines of Blaschko. Blaschko lines are consistently V-shaped on the upper spine, S-shaped on the abdomen, inverted U-shaped from the breast area to the upper arm, and perpendicular down the front and back of the lower extremities. first described Blaschko's lines, which are lines of typical cell development . COVID-19 Vaccine-Induced Lichenoid Eruptions—Clinical and Histopathologic Spectrum in a Case Series of Fifteen Patients. Blaschko's lines represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. A biopsy specimen showed a thinned epidermis devoid of rete ridges and vacuolar degeneration of the basal layer. Blaschko’s lines, also called the lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. One of the subjects developmental biologists are interested in is the development of pattern. In this study, we investigated clinical features and treatments of LPS by literature review of articles in the English language from PubMed and SCOPUS databases up to April 2018. Blaschko's lines, also called the Lines of Blaschko, are skin lines invisible under normal conditions. On the face, Blaschko lines typically run perpendicularly on the forehead, along the lateral aspects of the nose, and down to the chin. Blaschko's lines were firstly described by Alfred Blaschko in 1910. The lines of Blaschko delineate the lines of migration of epidermal cells during embryogenesis. Lichen striatus is an acquired, asymptomatic, and self-limited linear inflammatory skin disorder that predominantly affects children [ 1,2 ]. The objective of this study was to consider a hypothesis of the existence of Blaschko lines in the CNS in the example of incontinentia pigmenti (IP). Epidermal FIGURE 1 Clinical features and histopathological findings. A diagnosis of scalp mosaicism associated with widespread cutaneous mosaicism due to systematized sebaceous nevus was made. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. OBJECTIVE The aim of the study was to elaborate this pattern in. Certain unusual variants of LP may present a difficulty in diagnosis. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. The stripes on humans are called Blaschko’s lines, which were frst identified by dermatologist Alfred Blaschko in 1901. Blaschko’s lines are actually traces of the migration and proliferation of skin cells during embryonic development. Case Description Patient 1 A 16-year-old Vietnamese male presented with a 1-year history of hair loss of the scalp. com Open. Blaschko lines are manifestations of cutaneous mosaicism, with apparent contrast between normal cells and abnormal cells, which carry postzygotic mutations. , incontinentia pigmenti). Unilateral. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. When we start out as a single cell, and then a ball of cells, some of these cells become skin cells. Mosaic individuals are composed of two. (1987) reported 2 unrelated Japanese children with early-onset reticulate hyperpigmentation distributed in a zosteriform pattern along the lines of Blaschko on the trunk and limbs, but sparing the face, palms, and soles. He was otherwise healthy with no family history of au-toimmune diseases. Its constancy in Table 1 Linear dermatoses explained on the basis ofmosaicism. 3. As these cells divide and spread over the growing body, they form swirls and streams that create the lines of Blaschko. Blaschko lines correlate with mosaicism, regardless of the clinical presentation. German dermatologist Alfred Blaschko is credited with the first demonstration of these lines in 1901. General mosaicism: Occurs when there are two or more cell lines existing in a baby. Beilage zu den Verhandlungen der Deutschen Dermatologischen Gesellschaft VII Congress, Breslau, 1901. A recent study 20 reviewed thousands of photographs of congenital pigmentary disorders or vitiligo and defined the following three major patterns: (1) Blaschko's lines in narrow bands; (2) segmental "quadrilateral shapes"; and (3) nonsegmental "round shapes. This contribution provides an update on the diverse genetic etiologies, cutaneous findings,. They do not correspond to dermatomes, cranial nerve distribution, skin cleavage lines (Langer lines), skin tension lines, embryonic clefts, the lines of lymphatic drainage or blood supply, or hair tracts. have described linear and zosteriform lesions that were lateralized to the right side of the body along the lines of Blaschko. These lines are believed to be a result of the. Extragenital LS can occur in children as sclerotic atrophic plaques, most often appearing on the trunk and lower extremities . Blaschko’s Lines. Blaschko's lines map out a migratory history of ectodermal skin cells after their proliferation and movement from embryonic development into the fully formed organism [13]; further, skin disorders. Blaschko's lines are consistently V-shaped at the top of the spine, S-shaped across the abdomen, inverted U-shaped from the breast area to the upper arm, and perpendicular down the front and back of the lower extremities. Human skin is overlaid with what dermatologists call Blaschko’s Lines, a pattern of stripes covering the body from head to. It is caused by an altered clone of melanocytes (pigment cells) with a decreased ability to make melanin (brown pigment). The stripes on humans are called Blaschko’s lines,. Blaschko line, lichen planus, Blaschkoian lichen planus, zosteriform lichen planus. Blaschko: Die Neven-verteilung in der Haut in ihrer Beziehung zu den Erkrankungen der Haut. Danarti et al 4 postulated that LAM may reflect the action of an autosomal lethal gene surviving by mosaicism. Inherited factors in the affected skin, rather. genital and are arranged in a linear fashion following Blaschko’s lines. Since 1901, when Blaschko lines were first described, the study of mosasicism has helped to elucidate the. ” No conditions following Blaschko's lines in narrow bands had a genetic abnormality. Introduction Blaschko's lines (BL) are the surface patterns manifest by various nevoid and acquired skin diseases on the human skin and mucosa. Of all ACC cases, 70% are single lesions, 20% are double, and 8% are triple. Blaschko’s lines are invisible lines that are present on healthy skin. This is a review of case reports providing photographically documented evidence that the lines of Blaschko become manifest in. In fact, these are leftover from the time the person was a baby growing in the womb. The human stripes are visible only under UV light but invisible to th. We investigated a female Labrador Retriever and her crossbred daughter, which both showed similar clinical lesions that followed Blaschko's lines. Thomas et al. Three months later, the proband had several verrucous changes ( Figure 1B )], hyperpigmented maculas, and very few vesicles. BACKGROUND Linear atrophoderma of Moulin (LAM) is a dermatosis that affects children and adolescents characterized by hyperpigmented and atrophic. These lines are invisible under normal conditions. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. Unilateral distribution of lesions in arm, leg, trunk, and waist is even less common. We provide a simplified approach for the diagnosis of linear hyperpigmentation through two steps: 1 To determine whether hyperpigmentation follows Blaschko’s lines;. We do however hope that visitors to this site can contact us regarding comments that are considered. Blaschko’s lines are an invisible pattern on the skin that represents the developmental pathways of cells. 1998. The lines of Blaschko describe a linear pattern of distribution of various congenital, nevoid, and acquired skin disorders with their suspected embryological origins not yet well. The lines were discovered by German dermatologist Alfred Blaschko 75 years ago, Dr Bav Shergill, of the British Association of Dermatologists told MailOnline. The present CME article will highlight important skin disorders that primarily present in the form of one of the aforementioned patterns. Objective: The aim of the study was to elaborate this pattern in a comprehensive way. They were described and drawn by Blaschko 75 years ago. As its name would suggest, the skin lesions occur along Blaschko lines. Understanding the origins and significance of these lines can provide insights into the development and growth of the human body. This case presented with mild symptoms of MPS such as hepatosplenomegaly, joint stiffness, and quite mild bone deformity, which was the reason for the delay in diagnosis until the age. A 32-year-old Taiwanese man presented to our clinic with a 6-month history of linear hair loss in a wavy and curved pattern across the parietal and occipital scalp, resembling the distribution of Blaschko's lines. Disorders with a neuronal origin follow this pattern of distribution. 6 (1):p 56, Jan–Jun 2022. org. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal. 8Abstract. Blaschko's lines were delineated in 1901 by a German dermatologist Alfred Blaschko . They do not follow neural, vascular, or lymphatic structures and are distinct from dermatomes as well as Langer′s lines. Cutaneous lesions following Blaschko lines are a manifestation of cutaneous mosaicism. 1, 2 To the best of our knowledge, there is no existing clinical approach for linear hyperpigmentation diagnosis. This contribution provides an update on the diverse genetic etiologies. Oral antibiotic therapy is the mainstay of treatment. (C) Blaschko linear, erythematous and pigmented atrophic line with a verrucous part (6-months-old). Lichen planus is an uncommon disorder of unknown cause that most commonly affects middle-aged adults. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. 1,2 To the best of our knowledge, there is no existing clinical approach for linear hyperpigmentation diagnosis. The main purpose of this article is to introduce the concept of Blaschko's lines into the medical, paramedical, and general biological fields of science, and it is hoped that some inter‐reaction can occur between those who regularly see and study other chromosomal and embryological abnormalities. [] However, some cases of LS showing bizarre. This mysterious. Both HI and LWNH encompass heterogeneous groups of disorders characterized by conditions with hypopigmented or hyperpigmented skin. In 1901, the German dermatologist Alfred Blaschko described a system of cutaneous lines that represented the typical pattern that linear nevi appeared to follow. An epidermal naevus usually arises on the trunk and limbs and is uncommon on the face or scalp. Recognition that a cutaneous lesion follows Blaschko lines may represent an important clue for the diagnosis. They were described and drawn by Blaschko 75 years ago. On the chest and upper back they rise in a swirl before. Most commonly affect the scalp, then the preauricular region, face, and neck. (1989) provided a diagram of Blaschko lines, which were first described by Blaschko (1901). We report a case of an eight-year-old boy with mucopolysaccharidosis (MPS) II with atypical skin lesions of hyperpigmented streaks along Blaschko’s lines. Verrucous lesions were present at the same time with scarce vesicles. This characteristic skin lesion. It is characterized by unilateral linear pruritic eruptions along the Blaschko's lines, usually seen on the trunk. (A) Several small brownish erythema located linearly along Blaschko's line,Electronic address: Margie. Patches around the palpebral and other fissures like periorbital, perinasal, perioral, and periaural were more common. 1 Linear cutaneous lesions are those that occur along imaginary skin lines like Blaschko’s lines, lymphatics, and blood vessels or those with. They differ from dermatomes, and appear as single or multiple lines, whorls (swirls) and wave-like shapes in the skin. Histological examination was compatible with the clinical features. Blaschko’s lines are invisible lines that are present on healthy skin. A case of bilateral linear and annular lupus panniculitis following Blaschko's lines in a childConfluent and reticulated papillomatosis (CARP) is an uncommon dermatosis characterized by hyperpigmented scaly macules or papillomatous papules coalescing into confluent patches or plaques centrally with a reticular pattern peripherally ( picture 1A-D ). These lines were painstakingly and thoroughly documented first by German dermatologist Alfred Blaschko. The main event which allows the existence of mosaicism is a genetic mutation, either structural or functional. Over 100 years later, scientists agree the most likely explanation is that Blaschko lines trace the paths formed during embryonic development, as skin cells migrated and proliferated. Incontinentia pigmenti (IP) is a rare X-linked dominant disorder, in which skin lesions distributed along Blaschko's lines appear shortly after birth. They follow a “V” shape over the back,. The lines of Blaschko form a "V" shape over the spine, "S" shapes over the lateral and anterior aspects of the trunk, and a linear pattern over the extremities. The term "pigmentary mosaicism" refers to patterned hypo- or hyperpigmentation resulting from a clone of skin cells with altered ability to produce melanin [ 1 ]. Females with X-inactivation and skin pigment differences will show it under UV light. 起病突然，数周内全面进展，通常在6-12个月内消退。. 布拉什可氏線（英語： Blaschko's lines ），為根據皮膚的胚胎生長方向畫出之假想線 ，正常的人體無法看到布拉什可氏線，但某些皮膚和黏膜疾病會沿此線生長，而導致背部出現V字型的條狀病灶，胸部及側面出現S字形的條狀病灶，頭部則出現波浪狀病灶 。 布拉什可氏線是基因的鑲嵌現象 ，不會出現. German dermatologist Alfred Blaschko is credited with the first demonstration of these lines in 1901. Seventeen cases of childhood discoid lupus erythematosus (DLE) have been previously reported in the literature. The system of Blaschko's lines on the head and neck as elaborated by this study is more precise than previously published diagrams and shows definite crossing of lines. The archetypal figure has been subsequently updated by others and is represented elsewhere with greater detail in regions such as the head and neck (see Happle and Assim, 2001). On comparing the overlays of all body and head lesions with the original lines of Blaschko there was an excellent correlation. 1, 2, 3 The term linear LP was first used in 1976 to describe lesions along the lines of Blaschko, demonstrating a characteristic S shape on the abdomen, V shape near the. Finally, we differentiate Blaschko's lines from other. 1. The lines of Blaschko represent a pattern followed by many skin disorders. In 1901 the German dermatologist Alfred Blaschko published an atlas in which he described the lines of various linear skin diseases . Linear LP lesions are unilateral and distributed along Blaschko lines [4], [5]. Dermoscopy of linear dermatosis along Blaschko's line in childhood: Lichen striatus versus inflammatory linear verrucous epidermal nevusThe majority are distributed along the Blaschko line. Introduction Pigmentary mosaicism (PM) manifests by pigmentation anomalies along Blaschko’s lines and represents a clue toward the molecular diagnosis of syndromic intellectual disability (ID). JAMA Dermatology ( IF 10. The major function of this system is as a barrier against the external environment. LPP can present concomitantly with other variants of LP such as frontal fibrosing alopecia, as well as endocrinopathies, and autoimmune diseases. Blaschko's lines, also called the lines of Blaschko, are lines of normal cell development in the skin. CHARGE stands for coloboma, heart defect, atresia choanae (also known as choanal atresia), restricted growth and development, genital. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow. Hypomelanosis of Ito, initially referred to as incontinentia pigmenti achromians, is a rare neurocutaneous disorder. These lines follow a predictable pattern and usually appear in a V or S shape. This contribution provides an update on the diverse genetic etiologies, cutaneous findings, potential associated extracutaneous abnormalities, and management of various forms of pigmentary mosaicism. Blaschko's lines are the most common pattern of mosaicism. Numerous skin conditions, including genodermatoses, nevi, and inflammatory disorders can. The present author previously proposed that in addition to the line of migration, proliferation pattern of the embryonic cells at some later stage might have. These stripes, which are known as Blaschko’s lines, were discovered by dermatologist Alfred Blaschko in 1901. The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. Although in the initial description 1 extracutaneous findings were not reported, HI was later recognized as a. 10. Fungus that causes Athlete's. There have been many reports of congenital and acquired dermatosis that. Vitiligo is a common acquired depigmenting disorder of the skin and mucosa, affecting 0. Each patch of linear psoriasis represents one cell and all of the copies that it made. The three major clinical patterns are streaks and swirls following the Blaschko lines ( figure 1 ), a segmental or "checkerboard" distribution, and a phylloid (leaf-like) arrangement. 62% of all patients. IP is caused by loss-of-function mutations in the IKBKG (inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma) gene, formerly known as NEMO (nuclear factor. Uninterested because of frequent exposure or indulgence. Full size image. BACKGROUND The system of Blaschko's lines has been insufficiently documented on the head and neck. Lichen striatus (LS) is an uncommon, acquired, self-limited, and benign linear dermatosis of unknown etiology that most often occurs unilaterally and is confined to the lines of Blaschko. British Journal of Dermatology. 1A, B). In IP patients with neurological signs brain lesions usually were localized and extended radially. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. , 2006. These distinct types of archetypical arrangement should not. Cutaneous mosaicisms usually manifest by specific patterns on the skin and the archetypic pattern is the system of Blaschko lines, but others include checkerboard, phylloid, large patches without midline separation and lateralization. These lines are only visible in those with a mosaic The lines are believed to trace the migration of embryonic cells. They may be either visible at birth or become manifest dur - ing the first years of life. Disclaimer - the author PCDS cannot accept responsibility for any misleading or incorrect statements, and the management of individual patients remains the direct responsibility of the individual doctor.